Promega Corporation

Drug Discovery


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ADCC BioAssay Mechanism of Action 10338TA

A Better ADCC Bioassay

The ADCC Reporter Bioassay is ideal for quantifying Fc effector function of therapeutic antibodies, as measured by activation of NFAT signaling. The assay is based on ADCC mechanism of action, and is easier to use and less variable than classic ADCC assays.

Drug Discovery Categories

ADME Assays Our wide selection of bioluminescent enzyme substrates for proteases and metabolic enzymes such as CYPs and MAO, among others, provide powerful tools for the ADME-Tox screen.

Apoptosis Assays Get more data in less time when you multiplex cell health biomarkers. Measure one or multiple biomarkers in vitro or in situ to detect early or late events of apoptosis and get a quick status update on targeted cells.

Cell Viability Assays Promega cell viability assays allow easy measurement of the number of live cells/number of dead cells in a single well. The simple "add-mix-measure" protocols and convenient luminescent readout allow you to easily compare cell viability data from well-to-well, from plate-to-plate and from day-to-day.

Custom Assay Materials Advance your discovery programs by using research-grade materials built on the proven and versatile luciferase reporter systems and HaloTag® labeling technologies.

Cytotoxicity Assays Promega offers multiple readouts for quantifying cytotoxicity, including luminescent and fluorescent assays that can be multiplexed with apoptosis or viability assays to help determine mechanism of cell death.

Oxidative Stress Assays Promega offers assays for detecting glutathione, measuring the ratio of reduced to oxidized glutathione and detecting changes in ROS as an indicator of cell health or cell signaling events.

GPCR Assays Obtain better dynamic range and more biologically relevant data with the easy-to-use GloSensor™ assay format for live cell analysis.

Histone Deacetylase Assays Simple, "add-mix-measure" luminescent assays for detecting HDAC and Sirtuin enzyme activities.

Metabolism Assays

NAD+, NADP+, NADH and NADPH are important cofactors for many enzymes involved in key cellular pathways, and quantitation of these dinucleotides is a standard approach to monitor enzyme activity directly or indirectly. Promega offers a number of systems to detect and quantify these important molecules.

Nuclear Receptor Pathway Tools Follow nuclear receptor pathways with tools ranging from specific expression vectors to cell lines engineered to express your receptor of interest.

Protease Assays Bioluminescent, homogeneous protease assays provide rapid, simple and sensitive measurement of protease activities directly from the cellular environment. Maximum sensitivity can be reached within 10–30 minutes of reagent addition, making these assays ideal for HTS applications.

Kinase Assays Count on minimal interference from screening your compound library with luminescent, ATP-based kinase assays. These sensitive and reliable assays are easily scaled to meet your throughput needs.

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